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Magnetophoretic Cell Separation Technologies for Non-invasive Prenatal Diagnosis

Deirdre Kavanagh, Resh Dhariwal, Farid Amalou, Maiwenn Kersaudy Kerhoas, Dr David Flynn, Chris Popov, Sumanth Kumar Pavuluri, Elizabeth McKeever and Marc Desmulliez
Analysis of fetal genetic material extracted from maternal blood is a smart alternative to invasive prenatal testing such as amniocentesis... [read more]

Analysis of fetal genetic material extracted from maternal blood is a smart alternative to invasive prenatal testing such as amniocentesis. Separation of fetal cells from maternal blood is based on their natural intrinsic magnetic properties. The underlying separation principle relies on the paramagnetic behavior of deoxygenated RBCs. A micromagnetic separator has been designed and currently the first prototypes are being fabricated using biocompatible materials. The functionality of the prototype device will be tested using bovine and goose blood as models for adult human and fetal cells.

This project was part of current research under the 3-D MINTEGRATION consortium.