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Projects

Microsystems for the monitoring of Bacterial Response to Therapy (microBRT)
Researchers
Helen Bridle, David Watson, Marc Desmulliez, Maiwenn Kersaudy-Kerhoas
Keywords
Lab On Chip, microfluidics
Antibiotic resistance is a pressing issue in healthcare. We will address this with a new diagnostic concept and device. The device will use the response of bacterial pathogens to antibiotics in vivo at the mRNA level as a marker to guide antibiotic therapy of blood stream infections. Specific mRNA biomarkers were discovered and validated in other programmes at the University of Edinburgh. The final diagnostic device, beyond the scope of this project, should perform all necessary steps for mRNA detection, from sample to answer, at the point of care, integrated into one microfluidic device. The most challenging part in this process is the isolation of bacteria/mRNA from clinical specimens. Heriot Watt University has a proven track record in microfluidics, including nucleic acid isolation from blood. This study will investigate the feasibility of these technologies for the bacterial mRNA isolation, assessed by whole genome transcriptomics, directly from whole blood.
Sonopill
Researchers
David Watson, Julia Faerber, Gerard Cummins, Vasileios Mitrakos, Marc Desmulliez
Keywords
ultrasound, BioMEMS, Biosensors, packaging, wireless power transfer
Capsule endoscopy for diagnosis in the gastrointestinal (GI) tract has emerged only in the past ten years. Now established in several commercial products in companies such as Olympus and Medtronic and benefitting more than one million patients, it is a clear candidate for further innovation. The core of the SONOPILL programme is the exploration of ultrasound imaging and therapeutic capabilities deployed in capsule format. This is supported by extensive pre-clinical work to demonstrate the complementary nature of ultrasound and visual imaging, along with studies of multimodal diagnosis and therapy as the SONOPILL travels through the GI tract. This is opening up both challenges and opportunities in areas including ultrasound device and systems design, microengineering and microelectronic packaging, sensor suites for diagnosis and intervention, and routes to translation into clinical practice. Our programme's carefully structured but open-ended approach maximises the possibility to meet these challenges while delivering international leading science and engineering in multimodality capsule endoscopy. The ultimate aim is to provide greater capabilities for the clinician, more acceptable practice for the patient population, and lower costs for economic wellbeing.
Low Cost Magnetic Encoder
Researchers
David Watson, J. Gao, M.P.Y. Desmulliez
Keywords
LTCC, magetic encoder, position encoder
Using Low Temperature Co-fired Ceramic (LTCC) technology, this project aims to design, manufacture and test a cutting edge yet robust magnetic transducer system. Many high-resolution transducers work on optical principals, requiring complex and expensive components and sophisticated manufacture and assembly techniques. Optical transducers can be susceptible to contamination, such as dirt or oil, making them suitable only for clean operating environments or deployed behind complex, bulky seals. By contrast, transducers that work on magnetic principles can operate over a wide temperature range but have no delicate components and are immune to most foreign contaminants, making them ideal for deployment in harsh environment, e.g., industrial printing, robotics and machining centres. Today’s magnetic transducers of this type are largely based on planar 2D sensing coils manufactured using PCB technology, with resulting limits in sensitivity and resolution. The project will begin to investigate the development of a 3D transducer using low-cost LTCC technology.
Laser Direct-Writing of Metals on Polyimide Substrates
Researchers
David Watson, Jack Hoyd-Gigg Ng, Marc Desmulliez, Duncan Hand
Keywords
A novel packaging solution is being developed at Heriot-Watt University which focused on laser direct-writing of metal tracks, coils and circuits onto flexible polyimide substrates... [read more]
Novel RF Microfluidic Sensor for Particle-Cell Detection
Researchers
Elizabeth McKeever, S.K. Pavuluri, Mazher-Iqbal Mohammed, R. Lopez-Villarroya, G. Goussetis, M.P.Y. Desmulliez and D. Kavanagh
Keywords
A novel microfluidic sensing device based on waveguide cavity filters is proposed for the characterisation, detection of cells in solution and chemical substances in micro-litre volumes.
Design, test and biological validation of microfluidic systems for blood plasma separation
Researchers
Maiwenn Kersaudy Kerhoas, Deirdre Kavanagh, Resham Dhariwal, Marc Desmulliez
Keywords
BioMEMS, microfluidics, Lab On Chip
This projects aims at adressing the lack of lab-on-chip modules for sample preparation by proposing a blood plasma separator based on hydrodynamic principles only. This approach chosen is truly continuous meaning that both separated collections, blood cells and plasma can be recovered at the same time. Unlike others systems can handle large (3mL) and complex (whole blood) samples.
LTCC package integrated actuation for the dynamic alignment of optical components
Researchers
Stefan Wilhelm, Marc Desmulliez
Keywords
LTCC, actuator, 6DOF
The project focusses on the design and manufacturing of an LTCC-process compatible meso-scale actuator for the six degrees of freedom dynamic adjustment of micro-optical components.
Surface Acoustic Wave devices for the manipulation of fluids within microfluidic based systems
Researchers
Mazher-Iqbal Mohammed, Dave Flynn, Richard Fu and Mansour Algane
Keywords
microfluidics, Lab-on-a-chip, Surface Acoustic Waves
The application of SAW devices within microfluidics for advanced fluidic control and manipulation
Micro Total Analysis Systems (µTAS) for environmental based monitoring
Researchers
Mazher-Iqbal Mohammed, Dave Flynn, Mark Hartl
Keywords
microfluidics, BioMEMS, Lab-on-a-chip, Biosensors, E.Coli, Environmental
BioMEMS based detection for the environmental monitoring of E.Coli
BioMEMS solutions for the point of care detection of cardiac biomarkers
Researchers
Mazher-Iqbal Mohammed, Marc Desmulliez, Sir Keith Fox and Colin Campbell
Keywords
microfluidics, Lab-on-a-chip, BioMEMS, Cardiac, Biomarkers, Point of Care, Biosensors
Cardiovascular disease (CVD) accounts for approximately half of all the deaths within the Western World and costs the European Union approximately 192 billion Euros per year. Cardiac biomarkers are crucial in the triage and management of a range of cardiac related conditions where time delay has a major impact on short and longer-term outcomes and health of a patient. The elevation of specific cardiac biomarkers above clinically established baselines provides the clinician with information on the CVD related to a particular set of symptoms. Current clinical practices are failing to attain internationally recognised result turn-around times for diagnostic assays, delaying thereby initial treatment and increasing likelihood of patient mortality. This project aims at creating fully automated and complete PoC lab-on-a-chip device capable of detecting cardiac markers with high sensitivity and specificity from whole blood permitting a reduced diagnosis time for CVD related conditions. The primary emphases of this device will be on the integration of a high sensitivity biosensors within a microfluidic structure and the inclusion of integrated ‘on-chip’ optical components, to increase the detection sensitivity of the device compared to existing commercial PoC devices. The device envisaged will serve as a disposable module that will operate with a bespoke low-power, portable fluorescence reader suitable for PoC applications. The envisaged prototype will negate the requirements for alternative, more complex clinical examinations and will translate into financial savings and reduced turn-around time when implemented within a hospital and primary care setting, whilst also increasing the quality of patient care.
Non-invasive prenatal diagnosis
Researchers
Maiwenn Kersaudy Kerhoas, Deirdre Kavanagh, Mazher-Iqbal Mohammed, Resh Dhariwal, Farid Amalou, Elizabeth McKeever and Marc Desmulliez
Keywords
BioMEMS, microfluidics, Lab On Chip
Analysis of fetal genetic material extracted from maternal blood is a smart alternative to invasive prenatal testing such as amniocentesis and CVS. [Read More]
Frequency Agile Microwave Oven Bonding System
Researchers
Marc Desmulliez, George Gousettis, Sumanth Kumar Pavuluri, Keith Sinclair
Keywords
A novel open-ended microwave oven in the form of a waveguide cavity partially filled with dielectric is presented for combined spatially selective and uniform curing during flip-chip assembly. [read more]
A Micro Fabricated Current Sensor for Arc Fault Detection of Aircraft Wiring and Inter-Connect
Researchers
Brian Moffat, Marc Desmulliez
Keywords
MEMS, health monitoring
The research involved investigated the aging and failure mechanisms that can lead to catastrophic failure of aircraft wiring and interconnect.
Optical Packaging of Microlens over UV-LED-Array
Researchers
Markus Luetzelschwab, Dominik Weiland, Marc Desmulliez
Keywords
This work is part of a project entitled “One thousand emitters per square millimetres”, an EPSRC project funded under the Basic Technology Programme. The project is jointly run between Heriot-Watt University, ... [read more]
Haptic technology for virtual interaction
Researchers
Mustafa Calis, Jean-Baptiste Munier, Marc Desmulliez
Keywords
The potential MEMS market is growing very fast, but surprisingly, there is a lack of modelling and simulation methodology for precise performance verification of MEMS products... [read more].
Hermeticity Testing as Tool for Reliability and Failure Analysis of MEMS
Researchers
Suzanne Millar, Marc Desmulliez
Keywords
The aim of this project is to develop novel hermeticity test methods for MEMS. This project is in collaboration with MCS Ltd through the engineering doctorate scheme funded by the EPSRC.
High Density bumps for Micro-LED Array Flip-Chip Packaging
Researchers
David Flynn, Marc Desmulliez, Weixing Yu
Keywords
Micro-LED array as micro-light emitters has many potential applications in many areas such as microscopy, lab-on-chip screening and mask-free lithography et al.
Investigation of Polymer Bonding Processes for MEMS Packaging
Researchers
Kun Zhao, Changhai Wang
Keywords
Micro-electro-mechanical systems (MEMS) devices are fabricated using semiconductor processing techniques, which range in size from micrometers to millimetres... [read more]
Laser Assisted Polymer Bonding for MEMS Packaging
Researchers
Marc Desmulliez, Changhai Wang, Jun Zeng, Yufei Liu
Keywords
Microscale bonding and joining is a key process in manufacture of MEMS based products for encapsulation, assembly and packaging ... [read more]
Micro-Scale Magnetoelectric Composite Devices
Researchers
David Flynn, Chris Popov, Marc Desmulliez, Paul Record
Keywords
Earlier we demonstrated that macro-scale samples of magnetoelectric (ME) composites could be successfully used as magnetic energy harvesters ... [read more]
Remote and Non-Invasive Monitoring of Aircraft Wiring
Researchers
Gordon McKenzie, Paul Record
Keywords
The project is one of a number initiated by Ultra Electronics, that seeks to provide better monitoring of the wiring on military aircraft ... [read more]
The Application of LTCC and LCP technology in Microsystems Engineering and Opto-Electronic Devices
Researchers
Yves Lacrotte, Marc Desmulliez
Keywords
The main objective of this project is to develop packaging capabilities based on LTCC or LCP manufacturing technology. This technology platform is to be used for the production of optoelectronic packages ... [read more].
Development of a Flip-Chip Light Guide Package
Researchers
Dominik Weiland, David Flynn, Marc Desmulliez
Keywords
The goal of this collaborative project with Design LED Products Ltd. is to develop a unique LED package solution to couple light efficiently into thin (<0.1mm high) light-guides.
Fabrication and Characterisation of a Metal-based Microchannel Cooling Plate
Researchers
Marc Desmulliez, Weixing Yu
Keywords
The rapid advances in transistor density and switching frequency of VLSI circuits have induced dramatic increases in die heat flux and power consumption at all levels of electronic packaging... [read more]
Flip Chip Assembled MEMS Inductors for Wireless Communications
Researchers
Jun Zeng, Changhai Wang
Keywords
The aim of this project is to develop suspended MEMS inductors for wireless communications applications ... [read more]
MEMS Failure Modes and Reliability Modelling
Researchers
Suzanne Millar, Marc Desmulliez, Srikanth Lavu
Keywords
Reliability is the greatest challenge and has been a critical barrier to successful commercialization and wide acceptance of MEMS technology. [read more]
Miniaturised Optical Encoder
Researchers
John Carr, Marc Desmulliez
Keywords
Optical encoders are pervasive in almost all sectors of industry. However the critical alignment requirements between the optical gratings and to the photodiode array, ... [read more]
Optical Fibre Array Manufacture using Microengineering Techniques
Researchers
Dominik Weiland, Markus Luetzelschwab, Marc Desmulliez
Keywords
The work done in this project concentrates on the modelling, manufacture and characterisation of a novel method to manufacture two-dimensional bundles of single mode optical fibres of highly accurate pitch. [read more]
Design of a Three-Axis Accelerometer for Measurement of Heart Wall Motion
Researchers
Craig Lowrie, Marc Desmulliez
Keywords
This project comes under the title of the “MicroHeart Project” and its collaborators are Heriot-Watt University, Vestfold University College (Norway) and the Interventional Centre at Rikshospitalet University Hospital (Norway) ... [read more]
Cavity Based High Gain MEMS Antennas
Researchers
Sumanth Kumar Pavuluri, Changhai Wang
Keywords
The rapid development of wireless communications and the emerging demand for high frequency, high efficiency microwave devices and systems for sensing applications have prompted considerable interest ... [read more]
Magnetophoretic Cell Separation Technologies for Non-invasive Prenatal Diagnosis
Researchers
Deirdre Kavanagh, Resh Dhariwal, Farid Amalou, Maiwenn Kersaudy Kerhoas, Dr David Flynn, Chris Popov, Sumanth Kumar Pavuluri, Elizabeth McKeever and Marc Desmulliez
Keywords
BioMEMS, microfluidics, Lab On Chip
Analysis of fetal genetic material extracted from maternal blood is a smart alternative to invasive prenatal testing such as amniocentesis... [read more]
Development and Characterisation of Vapour Phase Sacrificial Etching and Organic Deposition for MEMS Fabrication
Researchers
Daniel Drysdale, Changhai Wang, Marc Desmulliez
Keywords
Vapour phase sacrificial etching and organic film deposition are key process steps in the manufacture of many MEMS devices. [read more]
ElectroHydrodynamic Instability Patterning (EHDIP)
Researchers
Scott Cargill, Marc Desmulliez
Keywords
EHDIP is a novel MEMS manufacturing process that makes use of the Instability of polymer materials when exposed to electric fields [read more]
Enhanced Electroplating of Vias using Megasonic Deposition
Researchers
Jens Kaufmann, Marc Desmulliez
Keywords
The Memsa project investigates the electroplating process and introduces enhancement technologies to increase its efficiency [read more]
Field Forming Antennas
Researchers
Claudio Biancotto, Paul Record
Keywords
Field Forming Antennas are a new class of Multiple Dielectric Antennas (MDA) intended to be used in microwave to mm-wave broadband with high bit rate communications systems ... [read more]
Simulation and Implementation of an Optical Encoder
Researchers
Luis Acevedo, Marc Desmulliez
Keywords
The incoherent wave front emitted from a LED can be modelled by analysing the Optical Scattered Distribution Function (BSDF) produced by the surface reflection of a Lambertian wave. [read more]
Axial-Flux Permanent Magnet Turbine for a Miniaturized Generator
Researchers
Chanwut Sriphung, Mark Leonard, Resh Dhariwal
Keywords
A microgenerator based on a MEMS microturbine is being developed for the purpose of power generation.